Rapamycin

Traditionally Rapamycin was used as a type of anti fungal antibiotic produced by steptomyces hygroscopicus. Currently it is being used in the prevention of transplant rejection because of its immunosuppressive effect. The immunosuppressive effect of Rapamycin is exerted by inhibiting the activation and proliferation of T cells. Rapamycin binds to FK-binding protein 12 (FKBP12) and forms the Rapamycin-FKBP12 complex, which regulates an enzyme that plays an important role in the progression of the cell cycle.